Everything you need for a sterile biotechnology process

Pharmaceuticals and vaccines produced using biotechnology are now a mainstay of the pharmaceutical industry. Biopharmaceuticals such as human insulin, interferons, new protein vaccines and monoclonal antibodies are commonly used in therapeutic applications, and an estimated 50% of all pharmaceuticals are expected to be produced using red biotechnology by 2020.

There is a fundamental difference between biopharmaceuticals and conventional “small” active ingredient molecules. Biopharmaceuticals are large molecular units that are produced in fermenters rather than using chemical pathways. They contain living, genetically modified microorganisms such as coli bacteria, yeast or mammalian cells which reproduce in the fermentation broth through mitosis. They function as cellular mini factories, producing the target biopharmaceuticals in the cell interior based on their genetic blueprint. During downstream processing, the cells are harvested and the biopharmaceuticals are extracted and purified until an end product is ready for delivery to doctors and patients.

In principle, it is all quite simple, but red biotechnology processes and production systems are among the most complex and sophisticated in the pharmaceutical industry. Creating a favorable environment where the microorganisms or mammalian cells can thrive and produce the target substances without interference is a major challenge.

Holistic fluid logistics ensure sterility and cleanability in biotech equipment

NEUMO high-grade ASME-BPE components and pharmaceutical tubing along with innovative, patented sterile technology such as CleanLip and LowVoid set new standards. They give the biotechnology industry what it needs to efficiently prevent foreign microorganisms, which would overwhelm and destroy the delicate cell cultures in the fermenters, from penetrating into their production systems. NEUMO offers its customers top-class holistic, validatable fluid logistics which ensure the sterility and cleanability of biotechnology systems and safeguard the integrity of the processes which take place in those systems.